Steven J Greco1, Pranela Rameshwar21Graduate School of Biomedical Sciences; 2Department of Medicine, Division of Hematology/Oncology, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark, NJ, USAAbstract: The therapeutic utilization of stem cells has been ongoing for several decades, principally in the form of bone m
IntroductionTherapies for Leber hereditary optic neuropathy (LHON), in common with all disorders caused by mutated mitochondrial DNA, are inadequate.We have developed two gene therapy strategies for the disease: mitochondrial-targeted and allotopic expressed and compared them in a mouse model of LHON.MethodsA LHON mouse model was generated by intra
Spinocerebellar ataxia type 1 (SCA1) is a dominantly inherited neurodegenerative disorder caused by polyglutamine repeat expansions in Ataxin-1.Recent evidence supports a role for microRNAs (miRNAs) deregulation in SCA1 pathogenesis.However, the extent to which miRNAs may modulate the onset, progression Astringents or severity of SCA1 remains large
Spinocerebellar ataxia type 1 (SCA1) is a dominantly inherited neurodegenerative disorder caused by polyglutamine repeat expansions in Ataxin-1.Recent evidence supports a role for microRNAs (miRNAs) deregulation in SCA1 pathogenesis.However, the extent to which miRNAs may modulate the onset, progression Astringents or severity of SCA1 remains large
The epithelial-to-mesenchymal transition (EMT) that occurs during embryonic development is recapitulated during tumor metastasis.Important regulators of this process include growth factors, transcription factors, and adhesion molecules.New evidence suggests that microRNA (miRNA) activity contributes to metastatic progression and EMT; however, the m